Liputan6.com, Jakarta - The American medical drama series, Grey's Anatomy, returns to its loyal fans with its highly anticipated 22nd Season.
The series, which centers on the personal and professional lives of surgeons at the fictional Grey Sloan Memorial Hospital, has become a global phenomenon since its premiere on March 27, 2005, on ABC as a mid-season replacement.
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This latest season will continue the high-intensity storytelling that is the hallmark of Grey's Anatomy, exploring the tough challenges and life-and-death decisions the medical staff faces every day.
Fans can look forward to the continuation of the story after the devastating explosion that rocked the hospital at the end of Season 21, an event that left one doctor injured and dead.
Season 22 will focus on the doctors' efforts to recover and rebuild amidst the destruction, while facing various personal and professional conflicts.
Grey's Anatomy Season 22 Thrilling Plot Sneak Peek
Grey's Anatomy Season 22 opens after the devastating explosion that rocked the hospital at the end of Season 21, causing the injury and death of a doctor.
The Grey Sloan staff struggles to save patients and themselves amidst the destruction.
The midseason episode, titled "Skyfall," aired on January 8, 2026, revealed the fate of Dr. Jo Wilson and her twins after the fall cliffhanger.
Jo suffered heart failure and required an emergency C-section for her twins, which was successfully performed by Winston Ndugu.
Although the babies were born with complications, Jo and her babies survived. Link (Chris Carmack) is devastated by Jo's condition.
Meanwhile, Miranda Bailey (Chandra Wilson) is deeply distressed by Richard's secret prostate cancer diagnosis.
Relationship drama also punctuates the season, with Simone (Alexis Floyd) breaking her no-sex pact with Jules (Adelaide Kane) by hooking up with Wes (Trevor Jackson).
Episode 8, "Heavy on Me," which airs on January 15, 2026, will feature Bailey and Owen working together to save a tumor patient.
Richard will face an "internal battle" regarding his illness, while Jules will struggle with her feelings for Winston.
Premiere Schedule and Details
Grey's Anatomy Season 22 was officially announced on April 3, 2025. It premiered in the United States on American Broadcasting Company (ABC) on October 9, 2025.
The season will consist of 18 episodes, the same number as Season 21.
The Season 22 midseason premiere returned on Thursday, January 8, 2026, at 10 p.m. EST on ABC.
New Season 22 episodes will continue to air throughout January 2026, with the eighth episode scheduled for January 15, 2026.
For streaming, episodes will be available on Hulu the day after their TV airing.
Meanwhile, Season 22 is expected to premiere on Netflix in the US in June 2026, and Netflix in Canada in Fall 2026.
Grey's Anatomy is a medical drama series developed by Shonda Rhimes, who also served as showrunner and executive producer until 2015.
The series' title is a combination of the main character's last name, Meredith Grey, and the classic human anatomy textbook "Grey's Anatomy."
The series surpassed its 450th episode in the second episode of Season 22, extending its record as the longest-running American primetime medical drama.
Grey's Anatomy Season 22 Casts
Grey's Anatomy Season 22 will feature the return of several beloved main cast members.
Ellen Pompeo will return as Dr. Meredith Grey, not only as narrator and executive producer, but also in seven episodes.
Chandra Wilson as Dr. Miranda Bailey and James Pickens Jr. as Dr. Richard Webber are the only original cast members confirmed to appear in all 18 episodes.
Other notable returning cast members include Kevin McKidd as Dr. Owen Hunt, Caterina Scorsone as Dr. Amelia Shepherd, Camilla Luddington as Dr. Jo Wilson, and Kim Raver as Dr. Teddy Altman.
Jason George also returns as the series regular Dr. Ben Warren following the conclusion of "Station 19."
Additionally, Trevor Jackson, who previously guest starred, has been promoted to series regular as Dr. Wes Bryant.
Unfortunately, Jake Borelli (Levi Schmitt) and Midori Francis (Mika Yasuda) are not returning as regular cast members this season.