Grey's Anatomy Season 22 Premiere: Everything You Need to Know

Liputan6.com, Jakarta The iconic medical drama series, Grey's Anatomy, has officially returned with its highly anticipated 22nd season.

The new season premieres on Thursday, October 9, 2025, at 10:00 PM ET/PT on ABC, continuing the intriguing and challenging story of the doctors at Grey Sloan Memorial Hospital.

The season premiere immediately plunges viewers into the tense aftermath of the massive explosion that ended the previous season.

The hospital staff must scramble to find their missing colleagues, rescue the injured, and cope with the devastation that has engulfed the medical facility.

With a storyline centered on the recovery efforts and aftermath of the tragedy, Grey's Anatomy Season 22 promises even more intense and emotional drama.

Fans can look forward to seeing their favorite characters navigate the trauma and inevitable changes that follow this horrific event.

It’s time. #GreysAnatomy season 22 starts now. pic.twitter.com/TY2Vo4sGkp

— Grey's Anatomy (@GreysABC) October 10, 2025

Grey's Anatomy was officially renewed for a 22nd season on April 3, 2025, ensuring the continuation of one of television's longest-running dramas.

The premiere in the United States will take place on October 9, 2025, at 10:00 PM ET/PT on ABC, with new episodes available to stream on Hulu the following day.

The season is expected to have 18 episodes, following the pattern of previous seasons, providing plenty of room for character development and in-depth storylines.

The second episode of season 22, titled "We Built This City," will be a milestone as it marks the 450th episode of the phenomenal series.

The show will air every Thursday, although there will likely be a mid-season break in November before returning in early 2026.

Grey's Anatomy's 22nd season opens shortly after the massive explosion that rocked Grey Sloan Memorial at the end of season 21, creating chaos and uncertainty.

The premiere episode, "Only the Strong Survive," focuses exclusively on the hospital staff's efforts to find their colleagues, rescue the injured, and cope with the devastation.

Showrunner Meg Marinis revealed that the main focus of the opening episode is "figuring out where everyone is, who's okay, and who's not."

Meredith Grey (Ellen Pompeo) even bravely breaks the clinic's glass door to help patients outside the hospital, demonstrating her unwavering dedication.

Several key characters, such as Dr. Atticus "Link" Lincoln (Chris Carmack) and Monica Beltran (Natalie Morales), are injured in the explosion, with Link being found trapped under the rubble.

Meredith's Alzheimer's research will continue to be a central part of the story, and she will spend more time in Seattle, with the possibility of returning to the operating room occasionally.

This season is also hinted at featuring internal conflict and "major departures or surprising twists" that will fuel plenty of drama, keeping viewers glued to the screen.

Season 22 of Grey's Anatomy brings back several key cast members who have become familiar faces to loyal fans.

Ellen Pompeo returns as Dr. Meredith Grey, although she will appear in seven episodes, continuing to narrate the story and serving as an executive producer.

In addition to Pompeo, veterans Chandra Wilson (Dr. Miranda Bailey), James Pickens Jr. (Dr. Richard Webber), Kevin McKidd (Dr. Owen Hunt), Kim Raver (Dr. Teddy Altman), Caterina Scorsone (Dr. Amelia Shepherd), and Camilla Luddington (Dr. Jo Wilson) also join the cast this season.

Jason George also returns as Dr. Ben Warren, along with Chris Carmack (Dr. Atticus "Link" Lincoln), Anthony Hill (Dr. Winston Ndugu), Alexis Floyd (Dr. Simone Griffith), Harry Shum Jr. (Dr. Benson "Blue" Kwan), Adelaide Kane (Dr. Jules Millin), and Niko Terho (Dr. Lucas Adams).

This season also welcomes Trevor Jackson, who previously guest-starred in season 21, who has been promoted to the series regular role as Dr. Wes Bryant.

Scott Speedman also returns part-time as Dr. Nick Marsh, and Debbie Allen will appear in a recurring role as Dr. Catherine Fox, adding depth to the already complex character dynamics.

Here's the broadcast schedule for the first few episodes of season 22:

• Episode 1: "Only the Strong Survive" — Airs October 9, 2025
• Episode 2: "We Built This City" — Airs October 16, 2025
• Episode 3: "Between Two Lungs" — Airs October 23, 2025
• Episode 4: "Goodbye Horses" — Airs October 30, 2025
• Episode 5: "Sometimes I Feel Like a Motherless Child" — Airs November 6, 2025
• Episode 6: "Title TBD" — Airs November 13, 2025